The use of the nitrite pathway (nitritation / denitritation) to reduce organic matter requirements and aeration costs is often recommended to improve the efficiency of municipal WWTPs. However, no previous studies have been conducted on what the minimum COD requirements would be to meet the total nitrogen and phosphorus discharge limits when integrating EBPR with the nitrite pathway. This work is a simulation-based study with a conventional Anaerobic/Anoxic/Oxic (A2O) WWTP where the nitrite pathway can be implemented. An ASM2d-N2O model with processes related to nitrite and N2O was used to study the effect of different influent compositions in order to obtain general recommendations to decide if the implementation of the nitrite pathway would be useful for a given wastewater. As a result of this study, general correlations and a practical decision tree were developed to provide useful recommendations for professionals in light of the design of A2/O WWTPs. These correlations are useful to calculate organic matter requirements that for influent composition in the ranges of 7-11 mgPO4-3-P·L-1 and 20-60 mg NH4+-N·L-1.